Six new 2-[4-bi-(4-fluorophenyl)-methylpiperazin-1-yl] acteyl hydrazones 3a～3f were synthesized. Under microwave irradiation conditions, 1-[bi-(4-fluorophenyl)methyl]-piperazine was reacted with ethyl chloroacetate in acetone to form ethyl 2-[4-bi-(4-fluorophenyl)-methylpiperazin-1-yl]acetate (1). Compoun 1 was reacted with hydrazine to give 2-[4-bi-(4-fluorophenyl)-methylpiperazin-1-yl]acteyl hydrazine (2) under microwave irradiation conditions. Treatment of the compound 2 with aromatic aldehydes under microwave irradiation yielded the corresponding compounds 2-[4-bi-(4-fluorophenyl)methylpiperazin- 1-yl] acteyl hydrazones 3a～3f with good yields. The structures of the six new compounds were confirmed by IR, 1H NMR, MS techniques and elemental analysis.

Key words: hydrazone, 1-[bi-(4-fluorophenyl)-methyl]piperazine, organic synthesis, microwave irradiation