Synthesis and Biological Activities of Novel Imine Derivatives  Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (01): 123-127. Previous Articles Next Articles

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新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物的合成及生物活性

戴红; 刘建兵 ; 张欣; 于海波; 秦雪;
秦振芳 ; 王婷婷; 方建新*

(南开大学元素有机化学国家重点实验室天津市农药科学重点实验室天津 300071)

收稿日期:2008-09-27 修回日期:2008-11-20 发布日期:2009-01-20
通讯作者: 方建新

Synthesis and Biological Activities of Novel Imine Derivatives Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings

Dai, Hong; Liu, Jianbing ; Zhang, Xin ; Yu, Haibo ; Qin, Xue;
Qin, Zhenfang ; Wang, Tingting ; Fang, Jianxin*

(State Key Laboratory of Elemento-organic Chemistry and Tianjin Key Laboratory of Pesticide Science,
Nankai University, Tianjin 300071)

Received:2008-09-27 Revised:2008-11-20 Published:2009-01-20
Contact: Fang, Jianxin

Abstract

Fourteen new imine derivatives 5 containing 2-substituted-1,3-thiazolidine and thiazole rings were synthesized by the condensation of 2-cyanoimino-3-(2-aminothiazol-4-ylmethyl)thiazolidine with various substituted benzaldehydes. The structures of the title compounds were characterized by 1H NMR spectra and elemental analysis. The structure of 5a was also determined by X-ray diffraction analysis. Preliminary bioassay showed that some of the target compounds exhibited fungicidal and plant growth regulatory activities to some extent.

Key words: thiazole, 2-substituted-1,3-thiazolidine, imine, biological activity, synthesis

Cite this article

Dai, Hong; Liu, Jianbing ; Zhang, Xin ; Yu, Haibo ; Qin, Xue;
Qin, Zhenfang ; Wang, Tingting ; Fang, Jianxin*
. Synthesis and Biological Activities of Novel Imine Derivatives Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings[J]. Chin. J. Org. Chem., 2009, 29(01): 123-127.

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新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物的合成及生物活性

Synthesis and Biological Activities of Novel Imine Derivatives Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings

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