Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (02): 279-282. Previous Articles     Next Articles

Reports

新型大环席夫碱化合物的合成及其抗菌活性研究

袁泽利; 胡庆红; 吴 庆; 张铭钦; 朱必学*   

  1. (a遵义医学院药学系 遵义 563003)
    (b贵州大学化学系 贵阳 550025)
  • 收稿日期:2008-04-13 修回日期:2008-08-15 发布日期:2009-02-20
  • 通讯作者: 朱必学

Synthesis and Antibacterial Activity of Novel Schiff Base Macrocyclic Compounds

Yuan, Zeli ; Hu, Qinghong; Wu, Qing ; Zhang, Mingqin ; Zhu, Bixue*   

  1. (a Department of Pharmacy, Zhunyi Medical College, Zhunyi 563003)
    (b Deparment of Chemistry, Guizhou University, Guiyang 550025)
  • Received:2008-04-13 Revised:2008-08-15 Published:2009-02-20
  • Contact: Zhu, Bixue

Using Ca2+ or Ba2+ as the template 2,4-dihydroxy-5-acetylacetophenone was reacted with a series of diamine to yield novel macrocyclic Schiff base compounds (Ln). Their structures were characterized by elemental analysis, 1H NMR, IR, UV-vis and MS techniques, and the in vitro antimicrobial activities were also tested.

Key words: template synthesis, Schiff base, antibacterial activity, diamine