Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 426-431. Previous Articles     Next Articles

Original Articles

双功能化Salen-Ti配合物催化芳香醛的不对称氰甲酸酯化反应研究

沈 淳; 仇文卫*; 汤 杰   

  1. (华东师范大学化学系 上海 200062)
  • 收稿日期:2008-07-11 修回日期:2008-10-30 发布日期:2009-03-20
  • 通讯作者: 仇文卫

Enantioselective Cyano-ethoxycarbonylation of Aldehydes Catalyzed by Bifunctional Salen-Ti Complex

Shen, Chun ; Qiu, Wenwei*; Tang, Jie   

  1. (Department of Chemistry, East China Normal University, Shanghai 200062)
  • Received:2008-07-11 Revised:2008-10-30 Published:2009-03-20
  • Contact: Qiu, Wenwei

Four bifunctional salen-Ti complexes were synthesized and applied to the addition reaction of ethyl cyanoformate to aromatic aldehydes. Under the optimized reaction condition, the catalyst showed excellent activity and good enantioselectivity, and the yields were 86%~95% with the highest 92% ee.

Key words: asymmetric catalysis, aromatic aldehyde, cyano-ethoxycarbonylation, salen-Ti