Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (05): 736-741. Previous Articles     Next Articles

Original Articles

(3S,6S)-及(3S,6R)-3-苄氧甲基-6-甲基-吗啉-2,5-二酮的 制备及其晶体结构

李 弘*; 焦洁平 ; 孔丽君; 焦志峰 ; 张来东; 徐 杰; 何培茹
  

  1. (南开大学高分子化学研究所 功能高分子材料教育部重点实验室 天津 300071)
  • 收稿日期:2008-07-30 修回日期:2008-10-20 发布日期:2009-05-20
  • 通讯作者: 李 弘

Synthesis and Crystal Structures of Chiral (3S,6S)- and (3S,6R)- 3-Benzyloxymethyl-6-methyl-morpholine-2,5-dione

Li, Hong*; Jiao, Jieping ; Kong, Lijun; Jiao, Zhifeng ;Zhang, Laidong ; Xu, Jie ; He, Peiru
  

  1. (Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry,
    Nankai University, Tianjin 300071)
  • Received:2008-07-30 Revised:2008-10-20 Published:2009-05-20
  • Contact: Li, Hong

N-(2-Bromopropionyl)-O-benzyl-L-serine (BPBS) was prepared using 2-bromopropionic acid and N-Boc-O-Bzl-L-serine as the starting reagents. BPBS underwent the intra-molecular ring-closing reaction in DMF/Et3N solvent at 80 ℃ for 9 h forming a mixture of two non-enantiomers, i.e. (3S,6S)-benzyloxy- methyl-6-methyl-morpholine-2,5-dione [(3S,6S)-BMMD] and (3S,6R)-BMMD with a yield of 70%. Two optically pure enantiomers of BMMD, i.e. (3S,6S)-BMMD and (3S,6R)-BMMD were obtained via 4 operation circles of “solution-partial recrystallization” by means of a differential recrystallization method using ethyl acetate as a solvent. The single crystals of the two isomers of BMMD were grown from ethyl acetate at room temperature. The fine molecular structures of the two isomers were determined by X-ray diffraction analysis of the single crystals.

Key words: (3S,6R)-benzyloxymethyl-6-methyl- morpholine-2,5-dione, crystal structure, resolution, optical isomer, (3S,6S)-benzyloxymethyl-6-methyl-morpholine-2,5-dione