The target compounds were synthesized by the reaction chloromethyl ester of (S)-naproxen with 1,4-dihydropyridine-3,5-dicarboxylic monoester in DMF in the presence of K₂CO₃, and purified by gradient crystallization or column chromatography on silica gel. The yields of seven new compounds were 21%～73%. The structures of the compounds were confirmed by ¹H NMR, IR and MS spectra. The effect of such new compounds on the contrac-tion of aorta smooth muscle was observed on the isolated arotic strips of rabbits, and most of them could re-lax constricting strip induced by phenylephrine.

Key words: synthesis, bioactivity, 1,4-dihydropyridine moiety substituted (S)-naproxen