Using N,N-dicyclohexylcarbodiimide (DCC) as dehydration reagent, eight new higher fatty acyl derivatives of D-ribofuranose were obtained by the reaction of 3-aminomethyl-α-D-ribofuranose or 3-benzamidomethyl-α-D-ribofuranose with higher fatty acids. The structures of all the new compounds were confirmed by spectral analysis. And the effect of the synthesized compounds to T-lymphocyte transformation was investigated using methyl thiazolyl tetrazolium (MTT) method. The result showed that the inhibitory bioactivities of the syn-thesized compounds with higher fatty acyl 4a～4d and 5a～5d to T-lymphocyte were higher than those of the compounds without higher fatty acyl 2 and 3.

Key words: higher fatty acid amide, higher fatty ester, synthesis, biological activity, D-ribofuranose