Chin. J. Org. Chem. ›› 1989, Vol. 9 ›› Issue (4): 363-366. Previous Articles     Next Articles

Original Articles

手性胺诱导的甲基多巴不对称合成

李伟;施耀曾;孙祥祯;范富龙;胡宏纹   

  1. 南京大学化学系
  • 发布日期:1989-08-25

Asymmetric synthesis of α-methyldopa via the induction of chiral amines

LI WEI;SHI YAOZENG;SUN XIANGZHEN;FAN FULONG;HU HONGWEN   

  • Published:1989-08-25

Reaction of 1-(3,4-methenedioxyphenyl)-2-acetone, chloroform, (+)-, (-)-PhCHMeNH2, and potassium hydroxide was carried out in dichloromethane-water at -5 to -10?with triethylbenzylammonium chloride as the phase transfer catalyst. The reaction products I were hydrogenolyzed and hydrolyzed to yield the (+)- and (-)-a-methyldopa.

Key words: PHASE TRANSFER CATALYSIS, AMINES, METHYLDOPA, CHIRALITY, MESOTOMY, INDUCTION

CLC Number: