Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (01): 42-52. Previous Articles     Next Articles

Review

Saframycins 及Ecteinascidins化合物的合成研究进展

王晔,唐叶峰 刘站柱*,陈世智,梁晓天   

  1. (中国医学科学院中国协和医科大学药物研究所 北京 100050)
  • 收稿日期:2004-03-01 修回日期:2004-06-01 发布日期:2004-12-30
  • 通讯作者: 刘站柱

Synthetic Progress in Saframycins and Ecteinascidins

WANG Ye,TANG Ye-Feng,LIU Zhan-Zhu*,CHEN Shi-Zhi,LIANG Xiao-Tian   

  1. (Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences,
    Beijing 100050)
  • Received:2004-03-01 Revised:2004-06-01 Published:2004-12-30
  • Contact: LIU Zhan-Zhu

The tetrahydroisoquinoline antitumor antibiotics have been studied thoroughly over the past 30 years. This paper reviews the synthetic progress in two kinds of bis-tetrahydroisoquinoline alkaloids, saframycins and ecteinascidins. The key reaction of each synthetic route has been analyzed. Both applications and limitations of these approaches were discussed. Some views on the biosynthesis and mechanism of action were summarized too.

Key words: saframycin, bis-tetrahydroisoquinoline alkaloid, ecteinascidin, synthesis, phthalascidin