Synthesis of Chirally Pure 4,4-Diphenylsubstituted Termi-nalAlkene Epoxides

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (03): 428-431. Previous Articles Next Articles

Original Articles

手性纯的4,4-二苯基取代的末端环氧化合物的合成

曹靖，李继超，欧阳昆冰，王攀登，阳年发*

(湘潭大学化学学院湘潭 411105)

收稿日期:2007-03-08 修回日期:2007-06-12 发布日期:2008-03-18
通讯作者: 阳年发

Synthesis of Chirally Pure 4,4-Diphenylsubstituted Termi-nalAlkene Epoxides

CAO Jing,LI Ji-Chao,OUYANG Kun-Bing,WANG Pang-Deng,YANG Nian-Fa*

(College of Chemistry, Xiangtan University, Xiangtan 411105)

Received:2007-03-08 Revised:2007-06-12 Published:2008-03-18
Contact: YANG Nian-Fa

Abstract

1,1-Diphenylalkyllithium, obtained from the reaction of the corresponding alkyllithium with 1,1-diphenylethylene, reacted with optically active epichlorohydrin at －70 ℃, then at room temprature under stirring for several hours to yield chirally pure 4,4-diphenylsubstituted terminal alkene epoxide with ＞90% ee. The reaction mechanism was discussed and the products were characterized by elemental analysis and NMR spectroscopy．

Key words: chiral, 4,4-diphenylsubstituted terminal alkene epoxide, synthesis

Cite this article

CAO Jing,LI Ji-Chao,OUYANG Kun-Bing,WANG Pang-Deng,YANG Nian-Fa*. Synthesis of Chirally Pure 4,4-Diphenylsubstituted Termi-nalAlkene Epoxides[J]. Chin. J. Org. Chem., 2008, 28(03): 428-431.

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手性纯的4,4-二苯基取代的末端环氧化合物的合成

Synthesis of Chirally Pure 4,4-Diphenylsubstituted Termi-nalAlkene Epoxides

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