Reductive Coupling of Heteroaryl Halides Catalyzed by Pd/C in Aqueous Media

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (05): 857-860. Previous Articles Next Articles

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水相中Pd/C催化的杂环芳卤的还原偶联反应研究

裴文*，董华

(浙江工业大学化学工程与材料学院杭州 310014)

收稿日期:2007-06-27 修回日期:2007-10-11 发布日期:2008-05-20
通讯作者: 裴文

Reductive Coupling of Heteroaryl Halides Catalyzed by Pd/C in Aqueous Media

PEI Wen*,DONG Hua

(College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014)

Received:2007-06-27 Revised:2007-10-11 Published:2008-05-20
Contact: PEI Wen

Abstract

Hetero biaryls were prepared with high yields from heteroaryl halides by Pd/C-catalyzed reductive coupling reaction in a H₂O-alcohol system. This method has advantages of environmental benignity, simplicity, the potential for recycling of catalyst, good yield and not using phase-transfer agent. The effects of various alcohols, bases and substrates on the reaction were discussed.

Key words: H₂O-alcohol, coupling, biaryl, aryl halide, Pd/C

Cite this article

PEI Wen*,DONG Hua. Reductive Coupling of Heteroaryl Halides Catalyzed by Pd/C in Aqueous Media[J]. Chin. J. Org. Chem., 2008, 28(05): 857-860.

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水相中Pd/C催化的杂环芳卤的还原偶联反应研究

Reductive Coupling of Heteroaryl Halides Catalyzed by Pd/C in Aqueous Media

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