Studies on the Synthesis of Novel Chalcone and Biological Activity

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (05): 690-693. Previous Articles Next Articles

Original Articles

新型查尔酮类化合物的合成及其生物活性研究

廖头根¹，汪秋安*^,1，方伟琴¹，朱华结²

(¹湖南大学化学化工学院长沙 410082)
(²中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明 650204)

收稿日期:2005-09-21 修回日期:2005-11-02 发布日期:2006-04-28
通讯作者: 汪秋安

Studies on the Synthesis of Novel Chalcone and Biological Activity

LIAO Tou-Gen¹,WANG Qiu-An*^,1,FANG Wei-Qin¹,ZHU Hua-Jie²

(¹College of Chemical and Chemistry Engineering, Hunan University, Changsha 410082)
(²State Key Laboratory of Photochemistry and Plant Resource in West China, Kunming Institute of Botany,
Chinese Academy of Sciences, Kunming 650204)

Received:2005-09-21 Revised:2005-11-02 Published:2006-04-28
Contact: WANG Qiu-An

Abstract

Eight novel chalcone compounds 1a～1h were synthesized by esterification, methoxymethyl protection or methylation, hydrazidation, oxidation, aldol condensation, deprotection, O-farnesylation or O-prenylation respectively using 3,5-dihydroxybenzoic acid as starting material in overall yield of 5.6%～46%. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and MS spectra. Target compounds were screened with three international stan-dard models for biological activity. Results showed that 1b against model CAT-B and 1e against model CDC25 possessed the good inhibition activity.

Key words: farnesyloxy chalcone, biological activity, prenyloxy chalcone, synthesis, hydroxylated chalcone

Cite this article

LIAO Tou-Gen,WANG Qiu-An*^,1,FANG Wei-Qin,ZHU Hua-Jie². Studies on the Synthesis of Novel Chalcone and Biological Activity[J]. Chin. J. Org. Chem., 2006, 26(05): 690-693.

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新型查尔酮类化合物的合成及其生物活性研究

Studies on the Synthesis of Novel Chalcone and Biological Activity

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