Synthesis, Spectral Characterization and Biological Activities of Phosphoryl Amino Acid Esters

Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (12): 1677-1681. Previous Articles Next Articles

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磷酰化氨基酸酯的合成、波谱表征及生物活性

蔡谊敏^a，高祥^a，黄现统^a，王统建^a，赵玉芬*^,a,b

(^a厦门大学化学化工学院化学生物学福建省重点实验室厦门 361005)
(^b清华大学化学系生命有机磷化学及化学生物学教育部重点实验室北京 100084)

收稿日期:2005-10-08 修回日期:2006-02-23 发布日期:2006-11-21
通讯作者: 赵玉芬

Synthesis, Spectral Characterization and Biological Activities of Phosphoryl Amino Acid Esters

CAI Yi-Min^a,GAO Xiang^a,HUANG Xian-Tong^a
WANG Tong-Jian^a,ZHAO Yu-Fen*^,a,b

(^aKey Laboratory for Chemical Biology of Fujian Province, Department of Chemistry,
Xiamen University, Xiamen 361005)
(^bKey Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education,
Department of Chemistry, Tsinghua University, Beijing 100084)

Received:2005-10-08 Revised:2006-02-23 Published:2006-11-21
Contact: ZHAO Yu-Fen

Abstract

Phosphoryl amino acids and phosphoryl amino acid esters, as phosphorus analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the title compounds, 2-isopropoxy-(2-isopropyl-5-methyl-cyclohexyloxy)-phosphoryl amino acid esters, were synthesized in the presence of sulfuryl chloride with reasonable yields. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR, ³¹P NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper.

Key words: sulfuryl chloride, biological activity, synthesis, spectra characterization, phosphonaminate

Cite this article

CAI Yi-Min^a,GAO Xiang^a,HUANG Xian-Tong^a
WANG Tong-Jian^a,ZHAO Yu-Fen*^,a,b. Synthesis, Spectral Characterization and Biological Activities of Phosphoryl Amino Acid Esters[J]. Chin. J. Org. Chem., 2006, 26(12): 1677-1681.

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磷酰化氨基酸酯的合成、波谱表征及生物活性

Synthesis, Spectral Characterization and Biological Activities of Phosphoryl Amino Acid Esters

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