One-pot Synthesis of 9-Aryl-1,2,3,4,5,6,7,8,9,10-decahydro- 1,8-acridinedione under Microwave Irradiation

Abstract

A series of 9-aryl-1,2,3,4,5,6,7,8,9,10-decahydro-1,8-acridinedione derivatives were synthesized via the reaction of aromatic aldehydes with 1,3-cyclohexanedione and ammonium acetate in solvent-free conditions under microwave irradiation by one-pot reaction. The reaction easily could be worked up with short reaction time, high yields and environmental friendliness. The structures of the products were confirmed by IR and ¹H NMR spectra. The structure of 3d was further determined by X-ray analysis.

Key words: microwave irradiation, acridinedione, 1,3-cyclohexanedione, aromatic aldehyde

Cite this article

HUA Guo-Ping^1,2,LI Tuan-Jie²,ZOU Xiang²,TU Shu-Jiang*^,2,ZHU Song-Lei²,ZHANG Xiao-Jing²,JI Shui-Jun³,ZHANG Yong³. One-pot Synthesis of 9-Aryl-1,2,3,4,5,6,7,8,9,10-decahydro- 1,8-acridinedione under Microwave Irradiation[J]. Chin. J. Org. Chem., 2005, 25(10): 1294-1297.

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微波辐射下一步合成9-芳基-1,2,3,4,5,6,7,8,9,10-十氢-1,8-吖啶二酮