Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (07): 826-829. Previous Articles     Next Articles

Original Articles

无溶剂条件下微波辐射合成2-氨基噻唑衍生物

成冲云,姜凤超*   

  1. (华中科技大学同济医学院药学院 武汉 430030)
  • 收稿日期:2004-10-15 修回日期:2005-01-24 发布日期:2005-06-30
  • 通讯作者: 姜凤超

Solvent Free Synthesis of 2-Aminothiazole Derivatives under Microwave Irradiation

CHENG Chong-Yun,JIANG Feng-Chao*   

  1. (School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030)
  • Received:2004-10-15 Revised:2005-01-24 Published:2005-06-30
  • Contact: JIANG Feng-Chao

Nine 2-aminothiazole derivatives were obtained under microwave irradiation condition by the reaction of thiourea, iodine and ketone in the absence of solvent. The reaction conditions were optimized by orthogonal design. The mechanism of the cyclization reaction under microwave irradiation was also suggested.

Key words: microwave irradiation, cyclization, reaction mechanism, synthesis, 2-aminothiazole