Synthesis of 3-Aminomethyl-4-trifluoromethylpyridine

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (9): 1637-1640. Previous Articles Next Articles

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3-氨甲基-4-三氟甲基吡啶的合成研究

李杰; 陈浩; 周勋; 陆秀宏 ; 陈国良*

(沈阳药科大学制药工程学院沈阳 110016)

收稿日期:2008-01-20 修回日期:2008-03-06 发布日期:2008-09-20
通讯作者: 陈国良

Synthesis of 3-Aminomethyl-4-trifluoromethylpyridine

LI, Jie; CHEN, Hao; ZHOU, Xun; LU, Xiu-Hong ;CHEN, Guo-Liang*

(School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016)

Received:2008-01-20 Revised:2008-03-06 Published:2008-09-20
Contact: CHEN, Guo-Liang

Abstract

A new convenient synthesis of 3-aminomethyl-4-trifluoromethylpyridine using 4,4,4-trifluoroa- cetoacetate and cyanoacetamide as precursors, via cyclization, chlorination, hydrogenolysis and hydrogenation under mild conditions, was achieved. In comparison with other methods, there are some advantages in this method: low-cost, easy purification, low equipment requirements and suitability for industrial scale-up.

Key words: 4,4,4-trifluoroacetoacetate, synthesis, 3-aminomethyl-4-trifluoromethylpyridine

Cite this article

LI, Jie; CHEN, Hao; ZHOU, Xun; LU, Xiu-Hong ;CHEN, Guo-Liang*. Synthesis of 3-Aminomethyl-4-trifluoromethylpyridine[J]. Chin. J. Org. Chem., 2008, 28(9): 1637-1640.

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3-氨甲基-4-三氟甲基吡啶的合成研究

Synthesis of 3-Aminomethyl-4-trifluoromethylpyridine

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