Peptide Nucleic Acid (PNA): Synthesis, Modifications andApplications

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Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (03): 254-263. Previous Articles Next Articles

Review

肽核酸的合成、修饰和应用

褚征，刘克良*

(军事医学科学院毒物药物研究所北京 100850)

收稿日期:2003-10-14 修回日期:2004-07-14 发布日期:2005-02-28
通讯作者: 刘克良

Peptide Nucleic Acid (PNA): Synthesis, Modifications andApplications

CHU Zheng, LIU Ke-Liang*

(Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)

Received:2003-10-14 Revised:2004-07-14 Published:2005-02-28

Contact: LIU Ke-Liang

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Abstract

Peptide nucleic acid (PNA) is DNA mimic, in which the sugar-phosphate backbone is replaced by a N-(2-aminoethyl)glycine polyamide structure. For optimizing the characteristics, various PNA monomers had been synthesized. The synthesis, modifications and applications of PNA are reviewed.

Key words: PNA, modification, application, synthesis

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CHU Zheng, LIU Ke-Liang*. Peptide Nucleic Acid (PNA): Synthesis, Modifications andApplications[J]. Chin. J. Org. Chem., 2005, 25(03): 254-263.

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[6]	Qianfan Zhao, Yongzheng Chen, Shiming Zhang. Application and Mechanism Study of Carbon-Based Metal-Free Catalysts in Organic Synthesis [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 137-147.
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[8]	Huakun Wang, Xiaolong Ren, Yining Xuan. Study of the Halide Salt Catalyzed [3＋2] Cycloaddition of α,β-Epoxy Carboxylate with Isocyanate [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 251-258.
[9]	Yukun Jin, Baoyi Ren, Fushun Liang. Visible Light-Mediated Selective C—F Bond Cleavage of Trifluoromethyl Groups and Its Application in Synthesizing gem-Difluoro-Containing Compounds [J]. Chinese Journal of Organic Chemistry, 2024, 44(1): 85-110.
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