Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (9): 1107-1109. Previous Articles     Next Articles

Reports

KF-Al2O3催化下吡喃并[2,3-d]嘧啶衍生物的一步合成

王香善*,1,2,3,曾兆森2,3,李玉玲2,3,史达清2,3
魏贤勇1,宗志敏1   

  1. (1中国矿业大学化学工程学院 徐州221008)
    (2徐州师范大学化学系 徐州221116)
    (3江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2004-11-04 修回日期:2005-03-15 发布日期:2005-08-24
  • 通讯作者: 王香善

One-pot Synthesis of Pyrano[2,3-d]pyrimidine Deriva-tivesCatalyzed by KF/Al2O3

WANG Xiang-Shan*,1,2,3,ZENG Zhao-Sen b,3,LI Yu-Ling b,3,SHI Da-Qing b,3
WEI Xian-Yong1,ZONG Zhi-Min1   

  1. (1 School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008)
    (2 Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (3 Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou 221116)
  • Received:2004-11-04 Revised:2005-03-15 Published:2005-08-24
  • Contact: WANG Xiang-Shan

A series of pyrano[2,3-d]pyrimidine derivatives have been synthesized by the reaction of aromatic aldehyde, malononitrile and 4,6-dihydroxylpyrimidine in EtOH at 80 ℃ catalyzed by KF/Al2O3. The structures of the products were characterized by IR, 1H NMR spectra and elemental analysis, and further confirmed by X-ray analysis.

Key words: pyrano[2,3-d]pyrimidine, synthesis, KF/Al2O3