Synthesis of Novel β-Dihydroxyarylporphyrins and Their
Interaction with DNA

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 79-84. Previous Articles Next Articles

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新型β-二酚卟啉光敏剂合成及其与DNA作用

黄齐茂，李志远，肖欣，潘志权*，邓鹏星

(武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室武汉 430073)

收稿日期:2009-05-16 修回日期:2009-06-30 发布日期:2010-01-20
通讯作者: 黄齐茂 E-mail:huangqim@163.com
基金资助:
国家自然科学基金（批准号：20471045）; 湖北省自然科学基金青年杰出人才项目（批准号: 2008CDB072）;国家级.国家自然科学基金

Synthesis of Novel β-Dihydroxyarylporphyrins and Their Interaction with DNA

Huang,Qimao，Li ,Zhiyuan，Xiao,Xin，Pan,Zhiquan*，Deng,Pengxing

(Key Laboratory for Green Chemical Process of Ministry of Education，School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology，Wuhan 430073)

Received:2009-05-16 Revised:2009-06-30 Published:2010-01-20

Abstract

Two kinds of novel β-dihydroxyarylporphyrins were synthesized by direct reaction of β-nitroporphyrin with 2,3-dihydroxynaphthalene and o-dihydroxybenzene respectively，and structurally characterized by UV，1H NMR，IR，MS and elemental analysis。The reaction mechanism was discussed。The agarose gel electrophoresis results show that the novel compounds cause significant cleavage to pBR322 plasmid DNA，which have good application prospects as photosensitizers or their precursors.

Key words: β-nitroporphyrin, photosensitizer, synthesis, characterization, DNA cleavage

CLC Number:

O626

Cite this article

HUANG Ji-Mao, LI Zhi-Yuan, XIAO Xin, BO Zhi-Quan, DENG Feng-Xing. Synthesis of Novel β-Dihydroxyarylporphyrins and Their Interaction with DNA [J]. Chin. J. Org. Chem., 2010, 30(01): 79-84.

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新型β-二酚卟啉光敏剂合成及其与DNA作用

Synthesis of Novel β-Dihydroxyarylporphyrins and Their Interaction with DNA

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