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Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (12): 1869-1889.     Next Articles

Reviews

抗流感药达菲(Tamiflu)合成纵览

孙 海a,b；林英杰b；吴毓林*,a；伍贻康*,a   

  1. (a中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032) (b吉林大学化学学院 长春 130012)
  • 收稿日期:2009-09-09 修回日期:2009-10-04 发布日期:2010-01-15
  • 通讯作者: 吴毓林 E-mail:ylwu@mail.sioc.ac.cn

A Survey of Synthetic Approaches to Anti-influenza Drug Tamiflu

Sun, Hai a,b；Lin, Yingjie b；Wu, Yulin *,a；Wu, Yikang *,a   

  1. (a State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) (b Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012)
  • Received:2009-09-09 Revised:2009-10-04 Published:2010-01-15

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Influenza is a highly infectious respiratory disease caused by virus, which in recent years has gradually become a substantial threat to the health of mankind. Because of the highly variable nature of the flu virus, chemotherapy of influenza has been very difficult. Up to now only a few drugs are available in the clinic treatment of influenza. In this review, synthetic routes to one of them, tamiflu, are surveyed.

Key words: influenza, anti-influenza drug, tamiflu, synthesis