Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (07): 1069-1071. Previous Articles     Next Articles

Full Papers

萘丁美酮合成的改进

陈小全*1,左之利2,仇玉芹3,周秀艳4,张昌军1,翟虎1,邵辉莹1,李保庆1   

  1. (1泰山医学院化学与化学工程学院 泰安 271000)
    (2中国科学院上海药物研究所 上海 201203)
    (3华东师范大学图书馆 上海 200062)
    (4四川大学化工学院 成都 610065)
  • 收稿日期:2009-09-08 修回日期:2009-12-06 发布日期:2010-02-11
  • 通讯作者: 陈小全 E-mail:chenxq98@163.com

Technological Improvement of Synthesis for Nabumetone

Chen Xiaoquan*1 Zuo Zhili2 Qiu Yuqin3 Zhou Xiuyan4 Zhang Changjun1 Zhai Hu1 Shao Huiying1 Li Baoqing1   

  1. (1Chemistry and Chemical Engineering School, Taishan Medical University, Taian 271000) (2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203) (3Library, East China Normal University, Shanghai 200062) (4Chemical Engineering School, Sichuan University, Chengdu 610065)
  • Received:2009-09-08 Revised:2009-12-06 Published:2010-02-11

In order to explore new method for synthesis of nabumetone, a synthetic method was investigated by the treatment of 2-methoxy naphthalene under ultrasonic irradiation. The time of the new synthesis method would be shortened from 13.5 h to 7.5 h and yield would be increased from 23.9% to 39.4%. The structure of the synthetic compound was identified by IR, MS and H NMR techniques.

Key words: synthesis, nabumetone, ultrasound, improvement