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Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (08): 1233-1236. Previous Articles     Next Articles

Notes

3-芳氧基丙醛系列化合物的合成研究

黄俊1,2，徐小英1，王立新*,1   

  1. (1中国科学院成都有机化学研究所 手性技术与不对称合成四川省重点实验室 成都 610041)
    (2中国科学院研究生院 北京 100039)
  • 收稿日期:2009-09-16 修回日期:2010-01-25 发布日期:2010-03-09
  • 通讯作者: 王立新 E-mail:wlxioc@cioc.ac.cn

Improved Preparation of 3-Aryloxypropanals

Huang Jun1,2 Xu Xiaoying1 Wang Lixin*,1   

  1. (1 Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu In-stitute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041)
    (2 Graduate University of Chinese Academy of Sciences, Beijing 100039)
  • Received:2009-09-16 Revised:2010-01-25 Published:2010-03-09
  • Contact: lixin wang E-mail:wlxioc@cioc.ac.cn

PDF

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3-Aryloxypropanals are important intermediates for the preparations of medicines, plasticizers and surfactants. An improved preparation of 3-aryloxypropanal is reported starting from substituted phenols, followed by coupling with 3-bromo-1,1-dimethoxypropane and deprotection in acidic condition in good (up to 82%) overall yield. The whole processes are mild, simple and reliable for larger scale preparations.

Key words: 3-aryloxypropanal, phenol, synthesis