Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (9): 1292-1304. Previous Articles Next Articles

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炔基锌与醛的催化不对称加成反应研究进展

李高伟¹，王晓娟²，赵文献*^{,1，郭保国¹，郑昕¹，王敏灿*^,2}

(¹商丘师范学院化学系有机新材料合成重点实验室商丘 476000)
(²郑州大学化学系河南省化学生物与有机化学重点实验室郑州 450052)

收稿日期:2009-11-05 修回日期:2010-01-11 发布日期:2010-03-04
通讯作者: 赵文献 E-mail:zhwx195812@yahoo.com.cn
基金资助:
国家级.国家自然科学基金

Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes

Li Gaowei¹ Wang Xiaojuan² Zhao Wenxian*^{,1 Guo Baoguo¹ Zheng Xin¹ Wang Mincan*^,2}

(¹ Key Laboratory of New Organic Materials Synthesis, Department of Chemistry, Shangqiu Normal University, Shangqiu 476000)
(² Henan Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052)

Received:2009-11-05 Revised:2010-01-11 Published:2010-03-04

Abstract

Optically active propargylic alcohols are important and versatile building blocks in asymmetric synthesis. The direct enantioselective addition of terminal alkynes to aldehydes is a very effective way in the synthesis of chiral secondary propargylic alcohols and has gained considerable significance. Research developments in the asymmetric addition of zinc alkynylides to aldehydes are reviewed according to different structure types of chiral ligands.

Key words: asymmetric synthesis, aldehyde, propargylic alcohol, alkynylation

Cite this article

LI Gao-Wei, WANG Xiao-Juan, ZHAO Wen-Xian, GUO Bao-Guo, ZHENG Xin, WANG Min-Can. Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes[J]. Chin. J. Org. Chem., 2010, 30(9): 1292-1304.

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炔基锌与醛的催化不对称加成反应研究进展

Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes

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