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Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (10): 1517-1520. Previous Articles     Next Articles

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一种含两对密集二硫键的模拟肽

吴巧玲1,2，刘珠果2，付超2，林原斌1，戴秋云*,2   

  1. (1湘潭大学化学学院 湘潭 411105)
    (2军事医学科学院生物工程研究所 北京 100071)
  • 收稿日期:2010-01-06 修回日期:2010-05-06 发布日期:2010-05-31
  • 通讯作者: 戴秋云 E-mail:qy_dai01@yahoo.com.cn
  • 基金资助:

    国家自然科学基金;国家“863”计划;国家“973”计划

A Mimetic Peptide with Two Pairs of Concentrated Disulfide Bridges

Wu Qiaoling1,2 Liu Zhuguo2 Fu Chao2 Lin Yuanbin1 Dai Qiuyun*,2   

  1. (1 College of Chemistry, Xiangtan University, Xiangtan 411105)
    (2 Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071)
  • Received:2010-01-06 Revised:2010-05-06 Published:2010-05-31
  • Contact: Qiuyun Dai E-mail:qy_dai01@yahoo.com.cn

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A small linear peptide of 11 amino acids (NTLCCEGCMCY-COOH) has been designed and synthesized based on cysteine framework (CC—C—C) of α-conotoxins and some amino acid residues of natural Conus imperialis conotoxin. In CH3COONH4 or NH4HCO3 buffer, this peptide form only one oxidative product with disulfide connectivity “C(1)—C(4), C(2)—C(3)” which is different from main forms of α-conotoxins [C(1)—C(3), C(2)—C(4)]. This mimetic α-conotoxin peptide possesses analgesic activity and con-tains most concentrated disulfide bridges reported to date, and could be used as drug design template.

Key words: mimetic peptide, synthesis, two disulfide bridge, oxidative folding