As a kind of important intermediates, isoxazolinium salts have been applied in the preparation of new compounds possessing considerable bioactivities. In this paper the structures and the synthesis methods of isoxazolinium salts are summarized, and its multiply intermediates functions are applied in the preparation of N-methylisoxazolidines, N-methylamino alcohols, N-methylamino polyols, α-amino acid and β-amino acids; at the same time the synthesis and application of new N-substituted isoxazolinium salts have been summarized. The developing and research direction are given based on the analysis of this research field.

Key words: isoxazolinium salt, synthesis, application