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Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (12): 1876-1883. Previous Articles     Next Articles

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6-甲基-4-(3-三氟甲基苯基)-3(2H)-哒嗪酮的合成与生物活性研究

许寒，胡绪红，刘斌，朱有全，邹小毛，胡方中，杨华铮*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2010-01-26 修回日期:2010-06-03 发布日期:2010-07-22
  • 通讯作者: 许寒 E-mail:xuhan@mail.nankai.edu.cn

Synthesis and Herbicidal Activity of Novel 6-Methyl-4-(3-trifluoro- methylphenyl)pyridazin-3(2H)-one

XU Han, HU Xu-Hong, LIU Bin, ZHU You-Quan, ZOU Xiao-Mao, HU Fang-Zhong, YANG Hua-Zheng   

  1. (Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2010-01-26 Revised:2010-06-03 Published:2010-07-22

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6-Methyl-4-(3-trifluoromethylphenyl)pyridazin-3(2H)-one (T-1) was designed and synthesized based on the comparative molecular field analysis (CoMFA) of three series herbicidal 3-trifluoromethyl- 1,1 -biphenyl derivatives inhibiting phytoene desaturase. Herbicidal activities of T-1 were evaluated through barnyardgrass, rape cup tests, Spirodela polyrrhiza (L.) and greenhouse test. T-1 exhibited good herbicidal and bleaching activites. Three methods for the preparation of T-1 were reported.

Key words: phytoene desaturase, synthesis, 6-methyl-4-(3-fluorotrimethylphenyl)pyridazin-3(2H)-one, bleaching activity, herbicidal activity