Ten novel 1-substituted piperidin-4-one arylformylhydrazones 9a～9j were synthesized with substituted benzylamines or primary amines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolytic decarboxylation reactions and hydrazone formation reactions. Their structures were elucidated and confirmed by ¹H NMR, IR, MS techniques and elemental analysis. The preliminary biologic activity tests indicate that some of the target compounds have good antiproliferative activities against K562 cells and have potential anti-leukemia bioactivity.

Key words: 1-substituted piperidin-4-one, arylformylhydrazone, synthesis, anti-leukemia bioactivity, K562, MTT