Synthesis of Oxalamide Compounds Containing Pyrimidine and Their Bioactivity on Tyrosinase of Diamondback Moth Plutella xylostella (L.)

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (04): 567-571. Previous Articles Next Articles

Notes

含嘧啶环乙二酰胺类化合物的合成及其对小菜蛾酪氨酸酶的抑制作用

王振¹，徐焱¹，董玮²，梁沛²，杨新玲*^,1

(¹中国农业大学理学院农业部农药化学与应用重点开放实验室北京 100193)
(²中国农业大学农学与生物技术学院北京 100193)

收稿日期:2010-03-22 修回日期:2010-11-15 发布日期:2010-12-03
通讯作者: 王振 E-mail:wz1022@163.com
基金资助:
863计划项目

Synthesis of Oxalamide Compounds Containing Pyrimidine and Their Bioactivity on Tyrosinase of Diamondback Moth Plutella xylostella (L.)

Wang Zhen¹ Xu Yan¹ Dong Wei² Liang Pei² Yang Xinling*^,1

(¹Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, College of Science, China Agricultural University, Beijing 100193)
(²College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193)

Received:2010-03-22 Revised:2010-11-15 Published:2010-12-03

Abstract

Tyrosinase is an important enzyme in insect. The development of insect can be affected by regulating its tyrosinase activity. In this paper, ten new oxalamide compouds containing pyrimidine were designed based on the mechanism of heteroatom chelation with kojic acid and cupferron. The title compounds were synthesized from the starting material of substituted aniline in 3 steps. Their structures were characterized by IR, ¹H NMR, MS and HRMS techniques. Meanwhile, their effects on the tyrosinase of the diamondback moth Plutella xylostella (L.) were tested. The bioassay result showed that some of the title compounds exhibited inhibitory effect on the tyrosinase.

Key words: oxalamide, tyrosinase, synthesis, biological activity

Cite this article

WANG Zhen, XU Yan, DONG Wei, LIANG Pei, YANG Xin-Ling. Synthesis of Oxalamide Compounds Containing Pyrimidine and Their Bioactivity on Tyrosinase of Diamondback Moth Plutella xylostella (L.)[J]. Chin. J. Org. Chem., 2011, 31(04): 567-571.

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含嘧啶环乙二酰胺类化合物的合成及其对小菜蛾酪氨酸酶的抑制作用

Synthesis of Oxalamide Compounds Containing Pyrimidine and Their Bioactivity on Tyrosinase of Diamondback Moth Plutella xylostella (L.)

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