Glaser coupling reaction has played an important role in the synthesis of 1,3-diynes, and has been extensively used in organic synthesis and material chemistry. The new research progresses on the Glaser coupling reaction involving in solvent, oxidant, and substrate were reviewed in this paper. It was pointed out that various researches on green chemistry of Glaser coupling reaction should be intensified continuously in the future. At the same time, the research on the Glaser coupling reaction of substrate with polyfunctional groups and the unsymmetric Glaser coupling reaction based on different substrate is also noteworthy.

Key words: glaser coupling reaction, solvent, oxidant, substrate, green chemistry