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Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1202-1207. Previous Articles     Next Articles

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2-[邻-4,6-二甲氧基嘧啶基-2-氧(硫)代苯基]-1,3,4-噻(噁)二唑类化合物的合成及其除草活性

张大永*,1，田庆海2，陆明若2，吴晓明1   

  1. (1中国药科大学新药研究中心 南京 210009)
    (2江苏常隆农药化工有限公司 常州 213031)
  • 收稿日期:2010-10-25 修回日期:2010-12-03 发布日期:2011-03-02
  • 通讯作者: 张大永 E-mail:zhangdayong@cpu.edu.cn

Synthesis and Herbicidal Activities of 2-(o-4,6-Dimethoxylpyrimidinyl- 2-oxo(thio)phenyl-1,3,4-thia(oxa)diazoles

Zhang Dayong*,1 Tian Qinghai2 Lu Min-gruo2 Wu Xiaoming1   

  1. (1 Center of Discovery Drug, China Pharmaceutical University, Nanjing 210009)
    (2 Jiangsu Changlong Pesticide Chemical Industry Co. Ltd., Changzhou 213031)
  • Received:2010-10-25 Revised:2010-12-03 Published:2011-03-02
  • Contact: Da-Yong ZHANG E-mail:zhangdayong@cpu.edu.cn

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The novel compounds 2-(o-4,6-dimethoxylpyrimidinyl-2-oxo-(thio)phenyl)-1,3,4-thia(oxa) diazoles were synthesized from substituted o-nitrobenzaldehyde or salicylaldehyde and o-mercaptobenzoni- trile by several steps. The employment dosage of 30% compound Ib was 2.40～3.60 L•hm－2, the rudiment cotton field herbicidal activities were over 48 d, and could lead to further research. The structures of target compounds were identified by IR, 1HNMS, MS techniques and elemental analysis.

Key words: thia(oxa)diazole, acetolactate synthetase, pyrithiobac-sodium, herbicide, synthesis