Condensation of 5-substituted-4-amino-3-mereapto-1,2,4-s-triazol 1a～1d with 1,3-dichloro-2-propanol gave the S,S-disubstitutedbis(amino-s-triazole) 2a～2d. The titled macrocycles 3a～3d were expediently prepared by condensation of 2,4-dihydroxy-5-acetylacetophenone with the appropriate 2 in the presence of polyethylene glycol 600. The structures of novel macrocyclic compounds 3 were characterized by elemental analysis, ¹H NMR, IR and MS techniques and the in vitro antimicrobial activities were also tested.

Key words: triazole, macrocyclic compound, Schiff base, synthesis, antibacterical activity