One-Pot Four-Component Synthesis of Dihydropyrano- [2,3-c]pyrazoles under Ultrasound Irradiations

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (12): 2161-2166. Previous Articles Next Articles

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超声作用下四组分一锅法合成二氢吡喃并[2, 3-c]吡唑衍生物

王慧彦*^,1，邹毅²，陶传洲¹

(¹淮海工学院化学工程学院连云港 222005)
(²徐州师范大学化学化工学院徐州 221116)

收稿日期:2011-01-17 修回日期:2011-06-23 发布日期:2011-08-26
通讯作者: 王慧彦 E-mail:wanghy0118@163.com

One-Pot Four-Component Synthesis of Dihydropyrano- [2,3-c]pyrazoles under Ultrasound Irradiations

Wang Huiyan*^,1 Zou Yi² Tao Chuan-zhou¹

(¹Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005)
(²School of Chemistry and Chemical Engineering, Xuzhou Normal Univer-sity, Xuzhou 221116)

Received:2011-01-17 Revised:2011-06-23 Published:2011-08-26
Contact: Hui-Yan WANG E-mail:wanghy0118@163.com

A simple, facile, efficient and one-pot synthesis of dihydropyrano[2,3-c]pyrazoles derivatives by the four-component reaction of aldehydes, hydrazine, ethyl acetoacetate (or ethylbutyrylacetate) and malononitrile in ethanol without any catalysts under ultrasound irradiations is described. The advantages of this method are high yield, shorter reaction time, mild condition and simple work-up procedures.

Key words: dihydropyrano[2,3-c]pyrazoles, ultrasound irradiation, multicomponent reaction

Cite this article

WANG Hui-Yan, ZOU Yi, TAO Chuan-Zhou. One-Pot Four-Component Synthesis of Dihydropyrano- [2,3-c]pyrazoles under Ultrasound Irradiations[J]. Chin. J. Org. Chem., 2011, 31(12): 2161-2166.

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超声作用下四组分一锅法合成二氢吡喃并[2, 3-c]吡唑衍生物

One-Pot Four-Component Synthesis of Dihydropyrano- [2,3-c]pyrazoles under Ultrasound Irradiations

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