Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1344-1349.DOI: 10.6023/cjoc1110121 Previous Articles     Next Articles

Notes

和厚朴酚桥连卟啉光敏剂合成与结构表征

黄齐茂, 王司卫, 邓鹏星, 周红, 胡学雷, 潘志权   

  1. 武汉工程大学化工与制药学院 绿色化工过程省部共建教育部重点实验室 武汉 430073
  • 收稿日期:2011-10-12 修回日期:2012-02-16 发布日期:2012-03-22
  • 通讯作者: 潘志权 E-mail:zhiqpan@163.com or huangqim@163.com
  • 基金资助:
    国家自然科学基金(No. 20471045);湖北省自然科学基金青年杰出人才(No. 2008CDB072);湖北省高等学校优秀中青年团队计划(2008)资助项目.

Synthesis and Characterization of Honokiol Bridged Porphyrins as Photosensitizers

Huang Qimao, Wang Siwei, Deng Pengxing, Zhou Hong, Hu Xuelei, Pan Zhiquan   

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073
  • Received:2011-10-12 Revised:2012-02-16 Published:2012-03-22
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 20471045), the Natural Science Foundation of Hubei Province (No. 2008CDB072), the Foundation for Midlife and Youth Excellent Innovation Group of Hubei Province (2008).

Four pairs of porphyrin isomers have been synthesized by reaction of 2-nitrotetraphenylporphyrin and its metallic complexes with 2-naphthol, 1,6-dibromohexane and honokiol respectively, and structurally characterized by UV-vis, 1H NMR, H-H COSY, IR, MS, and elementary analysis. The production of singlet oxygen under radiation was determined with DPBF as the quencher. Their photocleavage ability to pBR322 plasmid DNA has been tested by gel electrophoresis and the interaction with CT DNA was detected by UV-Vis spectroscopy preliminarily.

Key words: porphyrin, honokiol, synthesis, characterization, photosensitivity