Synthesis and Bioactivities of Novel 1-Phenyl-3-Methyl-5-Aryloxy-1H-Pyrazole-4- Carbaldehyde-O-((2-Chloropyridin-5-yl)methyl)oximes

doi:10.6023/cjoc1201292

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (06): 1060-1066.DOI: 10.6023/cjoc1201292 Previous Articles Next Articles

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1-苯基-3-甲基-5-芳氧基-1H-吡唑4-甲醛-O-((2-氯吡啶-5-基)甲基)肟的合成与生物活性

戴红^a, 施磊^a, 张海军^a, 李永强^b, 方建新^b, 石玉军^a

a 南通大学化学化工学院南通 226019;
b 南开大学元素有机化学研究所天津 300071

收稿日期:2012-01-29 修回日期:2012-03-05 发布日期:2012-04-11
通讯作者: 李永强, 石玉军 E-mail:daihong_2001@yahoo.com.cn, lyq@nankai.edu.cn
基金资助:
国家自然科学基金(No. 20772068)、南通市科技计划(Nos. K2010016, AS2010005, AS2011011)和南通大学自然科学基金(Nos.09Z010, 09C001)资助项目.

Synthesis and Bioactivities of Novel 1-Phenyl-3-Methyl-5-Aryloxy-1H-Pyrazole-4- Carbaldehyde-O-((2-Chloropyridin-5-yl)methyl)oximes

Dai Hong^a, Shi Lei^a, Zhang Hai-Jun^a, Li Yong-Qiang^b, Fang Jian-Xin^b, Shi Yu-Jun^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
b Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received:2012-01-29 Revised:2012-03-05 Published:2012-04-11
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21102077), the Science and Technology Projects Fund of Nantong City (Nos. K2010016, AS2010005, AS2011011), and the Science Foundation of Nantong University (Nos. 09Z010, 09C001).

Fourteen novel pyrazole oxime ether derivatives containing a 2-chloro-5-methyl pyridyl ring were synthesized by the reaction of 1-phenyl-3-methyl-5-aryloxy-1H-pyrazole-4-carbaldehyde oximes with 2-chloro-5-chloromethyl pyridine. The structures of all new compounds were confirmed by ¹H NMR, ¹³C NMR spectra and elemental analysis. Preliminary bioassay results indicated that some compounds exhibited certain fungicidal and plant growth regulatory activities.

Key words: substituted pyridine, pyrazole oxime, synthesis, bioactivities

Cite this article

Dai Hong, Shi Lei, Zhang Hai-Jun, Li Yong-Qiang, Fang Jian-Xin, Shi Yu-Jun. Synthesis and Bioactivities of Novel 1-Phenyl-3-Methyl-5-Aryloxy-1H-Pyrazole-4- Carbaldehyde-O-((2-Chloropyridin-5-yl)methyl)oximes[J]. Chin. J. Org. Chem., 2012, 32(06): 1060-1066.

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1-苯基-3-甲基-5-芳氧基-1H-吡唑4-甲醛-O-((2-氯吡啶-5-基)甲基)肟的合成与生物活性

Synthesis and Bioactivities of Novel 1-Phenyl-3-Methyl-5-Aryloxy-1H-Pyrazole-4- Carbaldehyde-O-((2-Chloropyridin-5-yl)methyl)oximes

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