Natural products play the most important role in the development of drugs. The design and synthesis of natural products hybrids seem to be a promising approach to increase the number and the diversity of compounds for pharmacological testing and were expected to disclose an avenue toward the development of valuable leads for medicinal applications. In this paper the synthesis of an aza-brazilin/1,3-diarylindan-based hybrid starting from 1,2-dimethoxy-benzene was reported. The synthesis finished in 9 steps including Friedel-Crafts acylation, Claisen condensation, Knoevenagel condensation, Nazarov cyclization, aminolysis of β-keto esters, α-hydroxylation of β-dicarbonyl compounds, reduction of ketone, amide and the intra- molecular Friedel-Crafts cyclization reaction.

Key words: aza-brazilin, natural products hybrid, 1,3-diarylindan, synthesis