Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety

doi:10.6023/cjoc201207020

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2373-2377.DOI: 10.6023/cjoc201207020 Previous Articles Next Articles

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含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究

童建颖^a, 石延霞^c, 刘幸海^b, 孙娜波^a,b, 李宝聚^c

a 浙江树人大学生物与环境学院杭州 310015;
b 浙江工业大学化学工程与材料学院杭州 310014;
c 中国农业科学院蔬菜花卉研究所北京 100014

收稿日期:2012-07-16 修回日期:2012-08-10 发布日期:2012-08-15
通讯作者: 刘幸海 E-mail:xhliu@zjut.edu.cn
基金资助:
国家自然科学基金(No. 21002090)、浙江省重点创新团队(No. 2010R50018-06)、“十二五”国家科技支撑计划(No. 2011BAE06B03-01)资助项目.

Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety

Tong Jianying^a, Shi Yanxia^c, Liu Xinghai^b, Sun Nabo^a,b, Li Baoju^c

a College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015;
b College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014;
c Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014

Received:2012-07-16 Revised:2012-08-10 Published:2012-08-15
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21002090), the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018-06), and the National Key Technologies R&D Program (No. 2011BAE06B03-01).

A series of novel 1,2,4-triazole derivatives were synthesized from o-fluorobenzoic acid, hydrazine hydrate, phenyl isothiocyanate by multi-step reactions. Their structures were characterized by ¹H NMR, MS and elemental analyses. The target compounds were evaluated for their fungicidal activities against Corynespora cassiicola, Pseudomonas syringae pv. Lachrymans, Pseudoperonospora cubensis and Sclerotinia sclerotiorum in vivo, and the results indicated that some of the title compounds displayed excellent fungicidal activities.

Key words: 1,2,4-triazole, synthesis, fungicidal activity, o-fluorobenzoic acid

Cite this article

Tong Jianying, Shi Yanxia, Liu Xinghai, Sun Nabo, Li Baoju. Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety[J]. Chin. J. Org. Chem., 2012, 32(12): 2373-2377.

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含邻氟苯基的1,2,4-三唑类衍生物的合成及杀菌活性研究

Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety

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