Synthesis of Benzene-Bridged Bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) Derivatives

doi:10.6023/cjoc201207037

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2354-2357.DOI: 10.6023/cjoc201207037 Previous Articles Next Articles

Notes

苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物的合成

方正东, 袁意, 叶华林

湖北师范学院化学与环境工程学院黄石 435002

收稿日期:2012-07-25 修回日期:2012-08-21 发布日期:2012-08-27
通讯作者: 方正东 E-mail:zdfangluo@sina.com
基金资助:
湖北省自然科学基金(No. 2010CDA061)资助项目.

Synthesis of Benzene-Bridged Bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) Derivatives

Fang Zhengdong, Yuan Yi, Ye Hualing

College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002

Received:2012-07-25 Revised:2012-08-21 Published:2012-08-27
Supported by:
Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

Bis-aza-Wittig reactions of ethyl 4-[(triphenylphosphanylidene)amino]-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate (iminophosphorane 1) with aromatic diisocyanate and nucleophilic reagents produced novel benzene-bridged bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) derivatives in the presence of EtONa in 56%～92% yields. The structures of compounds were confirmed by ¹H NMR, IR, MS and elemental analysis.

Key words: benzene-bridged, thiazolo[4,5-d]pyrimidin-7(6H)-one, multicomponent reaction, iminophosphorane

Cite this article

Fang Zhengdong, Yuan Yi, Ye Hualing. Synthesis of Benzene-Bridged Bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) Derivatives[J]. Chin. J. Org. Chem., 2012, 32(12): 2354-2357.

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苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物的合成

Synthesis of Benzene-Bridged Bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) Derivatives

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