Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (12): 2358-2362.DOI: 10.6023/cjoc201207047 Previous Articles     Next Articles

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3-(2-萘基)-1-苯基-吡唑-4-甲醛腙衍生物的简便合成与表征

阿布拉江·克依木, 王立举   

  1. 新疆大学化学化工学院 新疆石油天然气精细化工教育部&自治区重点实验室 乌鲁木齐 830046
  • 收稿日期:2012-07-31 修回日期:2012-08-15 发布日期:2012-08-22
  • 通讯作者: 阿布拉江·克依木 E-mail:ablajan209@hotmail.com
  • 基金资助:
    新疆维吾尔自治区自然科学基金(No. 2009211A02)资助项目.

Convenient Synthesis and Characterization of Hydrazone Derivatives of 3-(2-Naphthyl)-1-phenyl-pyrazole-4-carbaldehyde

Ablajan Keyume, Wang Liju   

  1. Key Laboratory of Oil & Gas Fine Chemical, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046
  • Received:2012-07-31 Revised:2012-08-15 Published:2012-08-22
  • Supported by:
    Project supported by the Natural Science Foundation of Xinjiang Uyghur Autonomous Region (No. 2009211A02).

In order to obtain novel hydrazone derivatives containing pyrazole and thiazole rings which possess certain biological activity, a series of 1-(3-β-naphthyl-1-phenylpyrazole-4-methylene)-2-(4-arylthiazol-2-yl)hydrazones were synthesized via two different methods including multi step reactions and one-pot synthetic route using 3-β-naphthyl-1-phenyl-pyra- zole-4-carbaldehyde as a starting intermediate. The products were obtained in good yield under ultrasonic irradiation condition rather than heating. The structures of products were characterized by 1H NMR, MS and elemental analysis. The preliminary bioassay showed that compounds 4b and 4d possess obvious protective effects on the PC12 cells injury induced by H2O2.

Key words: pyrazole, thiazole, hydrazone, synthesis, ultrasonic irradiation, one-pot reaction