Synthesis and Fungicidal Activities of Novel Quinazoline Derivatives Containing 1,2,4-Triazole Schiff-Base Unit

doi:10.6023/cjoc201209023

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (02): 370-374.DOI: 10.6023/cjoc201209023 Previous Articles Next Articles

Notes

含1,2,4-三唑席夫碱的新型喹唑啉类化合物的合成及其抗菌活性研究

刘军虎, 刘勇, 蹇军友, 鲍小平

贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室贵阳 550025

收稿日期:2012-09-18 修回日期:2012-11-09 发布日期:2012-11-20
通讯作者: 鲍小平 E-mail:baoxp_1980@yahoo.com.cn
基金资助:
贵州省农业科技攻关(No. 20093010)资助项目.

Synthesis and Fungicidal Activities of Novel Quinazoline Derivatives Containing 1,2,4-Triazole Schiff-Base Unit

Liu Junhu, Liu Yong, Jian Junyou, Bao Xiaoping

Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Received:2012-09-18 Revised:2012-11-09 Published:2012-11-20
Supported by:
Project supported by the Agricultural Science and Technology Foundation of Guizhou Province (No. 20093010).

Using 3-methyl-4-amino-1,2,4-triazole-5-thione, aromatic aldehydes and 4-chloroquinazoline as starting materials, fourteen novel quinazoline derivatives containing 1,2,4-triazole Schiff-base unit were synthesized. The structures of target compounds were fully characterized by IR, ¹H NMR, MS and elemental analysis. The preliminary bioassay showed that some compounds possessed certain fungicidal activities. At the concentration of 50 μg/mL, the inhibition rates of compound 6g against F. oxysporium, C. mandshurica and P. infestans were 71%, 72% and 58%, respectively.

Key words: 1,2,4-triazole Schiff-base, quinazoline, synthesis, fungicidal activity

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Liu Junhu, Liu Yong, Jian Junyou, Bao Xiaoping. Synthesis and Fungicidal Activities of Novel Quinazoline Derivatives Containing 1,2,4-Triazole Schiff-Base Unit[J]. Chin. J. Org. Chem., 2013, 33(02): 370-374.

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含1,2,4-三唑席夫碱的新型喹唑啉类化合物的合成及其抗菌活性研究

Synthesis and Fungicidal Activities of Novel Quinazoline Derivatives Containing 1,2,4-Triazole Schiff-Base Unit

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