Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (03): 640-642.DOI: 10.6023/cjoc201210005 Previous Articles     Next Articles

Notes

5-氨基酮戊酸盐酸盐的合成新方法

迟鹏利, 谢崔越, 林吉茂   

  1. 山东大学化学与化工学院 济南 250100
  • 收稿日期:2012-10-07 修回日期:2012-12-04 发布日期:2012-12-07
  • 通讯作者: 林吉茂 E-mail:linjm@sdu.edu.cn

A Novel Synthetic Method of 5-Aminolevulinic Acid Hydrochloride

Chi Pengli, Xie Cuiyue, Lin Jimao   

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2012-10-07 Revised:2012-12-04 Published:2012-12-07

In this paper, a novel synthetic method of 5-aminolevulinic acid (5-ALA) hydrochloride was described starting from cheap and easily available epichlorohydrin. The 5-aminolevulinic acid hydrochloride was obtained by Gabriel reaction, ring-opening, oxidation, substitution and hydrolysis. The results showed that the synthetic method has the advantages of materials being simply available, good overall yield, easily work-up and low cost.

Key words: epichlorohydrin, 5-aminolevulinic acid hydrochloride, synthesis