Synthesis Research Progress of Rofecoxib and Its Derivatives

doi:10.6023/cjoc201212050

Abstract

Rofecoxib is a novel non-steroidal anti-inflammatory drug, which is the representative of cyclooxygenase inhibitor. Taking rofecoxib would increase the risk of heart attack or stroke risk. Although rofecoxib withdrawal from the market due to cardiovascular risk, but its excellent analgesic and anti-inflammatory activity still has great research value and broad application prospect. Therefore, rofecoxib as a lead compound, has become a focus of research, from which researchers try to find good activity and little side effects rofecoxib derivatives. The research progress of rofecoxib and its derivatives is reviewed, including synthesis of rofecoxib and its derivatives.

Key words: rofecoxib, derivative, synthesis, research progress

Cite this article

Liu Gaizhi, Han Deen, Wang Peng, Liu Hongmin. Synthesis Research Progress of Rofecoxib and Its Derivatives[J]. Chin. J. Org. Chem., 2013, 33(08): 1674-1685.

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