Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

doi:10.6023/cjoc201301039

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (07): 1536-1539.DOI: 10.6023/cjoc201301039 Previous Articles Next Articles

Notes

吡啶-4-甲酰胺噁二唑化合物的合成及性质研究

郑娟^a, 陈雨^b, 吴孔丽^a, 冉春玲^a, 徐琰^a, 宋毛平^a

a 郑州大学化学与分子工程学院郑州 450001;
b 郑州大学基础医学院郑州 450001

收稿日期:2013-01-16 修回日期:2013-03-07 发布日期:2013-03-15
通讯作者: 徐琰 E-mail:xuyan@zzu.edu.cn
基金资助:
国家自然科学基金(No. 21171149)资助项目.

Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

Zheng Juan^a, Chen Yu^b, Wu Kongli^a, Ran Chunling^a, Xu Yan^a, Song Maoping^a

a College of Chemistry and Molecular Engineering, Zhengzhou 450001;
b College of Basic Medicine, Zhengzhou University, Zhengzhou 450001

Received:2013-01-16 Revised:2013-03-07 Published:2013-03-15
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21171149).

Four new 2,5-disubstituted 1,3,4-oxadiazole derivative N-(5-aromatic-1,3,4-oxadiazol-2-yl)picolinamides 2a～2d were obtained by condensation, oxidization and acylation reactions, with isonicotinic acid and single substituted aromatic aldehydes as raw materials. These compounds were characterized by IR, ¹H NMR and elemental analysis. Fluorescence test results indicated that Cu²⁺could make this series compounds fluorescence quenching, and Zn²⁺could only enhance the fluorescence intensity of N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]isonicotinamide (2b). Furthermore, those compounds all showed good fungicidal activity against the tested bacteria, and among them, N-(5-p-tolyl-1,3,4-oxadiazol-2-yl)isonicotinamide (2d) against Gibberella zeae was reached 100%.

Key words: 1,3,4-oxadiazole, fluorescence, biological activity

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Zheng Juan, Chen Yu, Wu Kongli, Ran Chunling, Xu Yan, Song Maoping. Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles[J]. Chin. J. Org. Chem., 2013, 33(07): 1536-1539.

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吡啶-4-甲酰胺噁二唑化合物的合成及性质研究

Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

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