Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

doi:10.6023/cjoc201305045

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2155-2161.DOI: 10.6023/cjoc201305045 Previous Articles Next Articles

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四种天然双异戊烯基黄酮的合成及其抑菌活性研究

杨金会, 谢一民, 冯尚彪, 左武标, 陈兵兵, 马晓琴, 冯尧

宁夏大学天然气转化国家重点实验室培育基地银川 750021

收稿日期:2013-05-27 修回日期:2013-06-13 发布日期:2013-06-25
通讯作者: 杨金会 E-mail:yang_jh@nxu.edu.cn
基金资助:
国家自然科学基金(No.21162021);教育部“新世纪优秀人才支持计划”(No. NCET-09-0860)资助项目

Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

Yang Jinhui, Xie Yimin, Feng Shangbiao, Zuo Wubiao, Chen Bingbing, Ma Xiaoqin, Feng Yao

State Key Laboratory Cultivation Base of Natural Gas Conversion, Ningxia University, Yinchuan 750021

Received:2013-05-27 Revised:2013-06-13 Published:2013-06-25
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21162021) and the Program for New Century Excellent Talents in University (No. NCET-09-0860).

Abyssinone-Ⅴ, 4'-hydroxy-6,3',5'-triprenylisoflavonone, abyssinone-Ⅵ and abyssinone-Ⅳ were all isolated from the genus erythrina. This study completed the first total synthesis of four natural prenylated flavanoids by using simple and facile approaches. The result of their in vitro antibacterial tests indicated that all of them displayed moderate bacteriostatic activities. The compounds abyssinone-Ⅳ and abyssinone-Ⅴ showed remarkable antibacterial activities. The structures of all new compounds have been confirmed by HRMS, ¹H NMR and ¹³C NMR spectra.

Key words: prenylated flavanoid, (±)-abyssinone-Ⅵ, (±)-abyssinone-Ⅳ, (±)-abyssinone-Ⅴ, 4'-hydroxy-6,3',5'-triprenyli-soflavonone, total synthesis, antibacterial activity

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Yang Jinhui, Xie Yimin, Feng Shangbiao, Zuo Wubiao, Chen Bingbing, Ma Xiaoqin, Feng Yao. Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids[J]. Chin. J. Org. Chem., 2013, 33(10): 2155-2161.

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四种天然双异戊烯基黄酮的合成及其抑菌活性研究

Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

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