Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2596-2601.DOI: 10.6023/cjoc201307006 Previous Articles     Next Articles



谢峰a, 刘婷婷a, 杨果a, 袁静b, 孔小林a,b, 许天明b, 谭成侠a   

  1. a 浙江工业大学化学工程与材料学院 杭州 310014;
    b 中化蓝天浙江省化工研究院有限公司 杭州 310023
  • 收稿日期:2013-07-04 修回日期:2013-08-01 发布日期:2013-08-29
  • 通讯作者: 许天明, 谭成侠
  • 基金资助:

    “十二五”国家科技攻关计划项目(No. 2011BAE06B03-01)和浙江省重点科技创新团队(No. 2010R50018)资助项目.

Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives

Xie Fenga, Liu Tingtinga, Yang Guoa, Yuan Jingb, Kong Xiaolina,b, Xu Tianmingb, Tan Chengxiaa   

  1. a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014;
    b Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023
  • Received:2013-07-04 Revised:2013-08-01 Published:2013-08-29
  • Supported by:

    Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03-01) and the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018).

To find new lead compounds with high acaricidal bioactivity, ten new 1H-pyrazole-4-carboxamide derivatives were designed and synthesized by combining with the 1,3,5-trimethyl-1H-pyrazole-4-carboxamide moiety in pyflubumide and diaryl ether moiety in flufenoxuron. Their structures were confirmed by 1H NMR, MS and elemental analyses. The acaricidal activities of these compounds were evaluated by pesticide bioassay procedure. The results showed that most of title compounds exhibited significant effect against Tetranychus cinnabarinus with 90.0% death rate at 500 mg/L.

Key words: 1H-pyrazole-4-carboxamide, synthesis, acaricidal activity