Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives

doi:10.6023/cjoc201307006

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2596-2601.DOI: 10.6023/cjoc201307006 Previous Articles Next Articles

Notes

新型1H-吡唑-4-甲酰胺类衍生物的合成及杀螨活性

谢峰^a, 刘婷婷^a, 杨果^a, 袁静^b, 孔小林^a,b, 许天明^b, 谭成侠^a

a 浙江工业大学化学工程与材料学院杭州 310014;
b 中化蓝天浙江省化工研究院有限公司杭州 310023

收稿日期:2013-07-04 修回日期:2013-08-01 发布日期:2013-08-29
通讯作者: 许天明，谭成侠 E-mail:tanchengxia@zjut.edu.cn
基金资助:
“十二五”国家科技攻关计划项目(No. 2011BAE06B03-01)和浙江省重点科技创新团队(No. 2010R50018)资助项目.

Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives

Xie Feng^a, Liu Tingting^a, Yang Guo^a, Yuan Jing^b, Kong Xiaolin^a,b, Xu Tianming^b, Tan Chengxia^a

a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014;
b Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023

Received:2013-07-04 Revised:2013-08-01 Published:2013-08-29
Supported by:
Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03-01) and the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018).

To find new lead compounds with high acaricidal bioactivity, ten new 1H-pyrazole-4-carboxamide derivatives were designed and synthesized by combining with the 1,3,5-trimethyl-1H-pyrazole-4-carboxamide moiety in pyflubumide and diaryl ether moiety in flufenoxuron. Their structures were confirmed by ¹H NMR, MS and elemental analyses. The acaricidal activities of these compounds were evaluated by pesticide bioassay procedure. The results showed that most of title compounds exhibited significant effect against Tetranychus cinnabarinus with 90.0% death rate at 500 mg/L.

Key words: 1H-pyrazole-4-carboxamide, synthesis, acaricidal activity

Cite this article

Xie Feng, Liu Tingting, Yang Guo, Yuan Jing, Kong Xiaolin, Xu Tianming, Tan Chengxia. Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives[J]. Chin. J. Org. Chem., 2013, 33(12): 2596-2601.

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新型1H-吡唑-4-甲酰胺类衍生物的合成及杀螨活性

Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives

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