Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (2): 429-433.DOI: 10.6023/cjoc201307023 Previous Articles     Next Articles

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新型5,6-2H-Lamellarin η及其类似物全合成研究

王爱玲a,c, 郑学良a,b, 赵壮志a,b, 李长平a, 陶波c, 郑学仿a,b   

  1. a 大连大学环境与化学工程学院 大连 116622;
    b 大连大学辽宁省生物有机化学重点实验室 大连 116622;
    c 东北农业大学农学院 哈尔滨 150030
  • 收稿日期:2013-07-16 修回日期:2013-09-18 发布日期:2013-10-10
  • 通讯作者: 郑学仿 E-mail:dlxfzheng@126.com
  • 基金资助:

    国家自然科学基金(No.21271036)、大连市优秀青年科技人才基金(No.2009J22DW038)资助项目.

Synthesis of Novel 5,6-2H-Lamellarin η and Analogues

Wang Ailinga,c, Zheng Xuelianga,b, Zhao Zhuangzhia,b, Li Changpinga, Tao Boc, Zheng Xuefannga,b   

  1. a College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    b Liaoning Key Laboratory of Bio-organic Chemistry, Dalian University, Dalian 116622;
    c College of Agronomy, Northeast Agricultural University, Harbin 150030
  • Received:2013-07-16 Revised:2013-09-18 Published:2013-10-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21271036) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

According to the reaction of "Knorr condensation-esterification-cyclization", the target compounds, 6-2H- lamellarin η (5a) and analogues 5b were synthesized successfully from 2,4-diisopropoxy-α-bromo-acetophenone compounds 1a, 1b and the isoquinoline compound 1c. Two kinds of novel open-chain lamellarins (compounds , ) were accompanied to obtain during the synthesis of 5a. In this paper, ten compounds had been got including six new compounds, which are identified by 1H NMR, 13C NMR, MS, IR, HRMS techniques.

Key words: 5,6-2H-lamellarin η, synthesis, Knorr condensation