Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas

doi:10.6023/cjoc201404040

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (10): 2140-2145.DOI: 10.6023/cjoc201404040 Previous Articles Next Articles

Notes

新型含甲氨甲酰苯基烟酰脲类化合物的设计、合成及生物活性研究

刘建华^a, 李以名^b, 毛达杰^a, 杜晓华^a

a. 浙江工业大学催化加氢中心浙江省绿色农药清洁生产技术研究重点实验室杭州 310014;
b. 嘉兴学院生物与化学工程学院嘉兴 314001

收稿日期:2014-04-22 修回日期:2014-05-16 发布日期:2014-06-11
通讯作者: 杜晓华 E-mail:duxiaohua@zjut.edu.cn

Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas

Liu Jianhua^a, Li Yiming^b, Mao Dajie^a, Du Xiaohua^a

a. Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Catalytic Hydrogenation Research;
Center, Zhejiang University of Technology, Hangzhou 310014;
b. College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001

Received:2014-04-22 Revised:2014-05-16 Published:2014-06-11

1. Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas.PDF(1431KB)

Abstract

In order to look for new pesticidal leading compounds, 12 novel nicotinoyl ureas were designed and synthesized based on the structure fragments of chlorantraniliprole and 2-chloronicotinic acid according to the bio-rational design principle. The structures of all compounds have been confirmed by ¹H NMR, ¹³C NMR, IR and HRMS techniques. The preliminary results of biological sceen indicated that some of the title compounds exhibited high insecticidal activities against Mythimna separate. At 500 mg/L, compounds 5a, 5g and 5h exhibited a insecticidal activity of 100%. In additional, some compounds showed herbicidal activities, such as 100 mg/L of compounds 5f inhibited 80% root growth against Echinochloa crusgalli.

Key words: chlorantraniliprole, 2-chloronicotinic acid, synthesis, insecticidal activity, herbicidal activity

Cite this article

Liu Jianhua, Li Yiming, Mao Dajie, Du Xiaohua. Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas[J]. Chin. J. Org. Chem., 2014, 34(10): 2140-2145.

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新型含甲氨甲酰苯基烟酰脲类化合物的设计、合成及生物活性研究

Design, Synthesis and Bioactivities of Novel N-Methyl-carbamoylphenyl Nicotinoyl Ureas

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