Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones

doi:10.6023/cjoc201509011

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 393-398.DOI: 10.6023/cjoc201509011 Previous Articles Next Articles

Notes

1-(吡啶-2-基)-2-芳氧基-2-(α-1H-1,2,4-三唑-1-基)乙酮的合成、晶体结构与生物活性

戴红^a,b, 刘建兵^a, 陶伟峰^a, 苗文科^a, 方建新^a, 汪清民^a

a 南开大学元素有机化学国家重点实验室天津 300071;
b 南通大学化学化工学院南通 226019

收稿日期:2015-09-08 修回日期:2015-09-30 发布日期:2015-11-03
通讯作者: 戴红, 方建新 E-mail:daihong_2001@aliyun.com;yssfjx@yahoo.com.cn
基金资助:
国家自然科学基金(Nos. 20772068)、元素有机化学国家重点实验室开放课题(No. 201412)和南通市科技计划(Nos. CP12013002, AS2014011)资助项目

Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones

Dai Hong^a,b, Liu Jianbing^a, Tao Weifeng^a, Miao Wenke^a, Fang Jianxin^a, Wang Qingmin^a

a State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
b College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019

Received:2015-09-08 Revised:2015-09-30 Published:2015-11-03
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20772068), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), and the Science and Technology Project Fund of Nantong City (Nos. CP12013002, AS2014011)

1. Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones.PDF(566KB)

Abstract

In order to find novel triazole lead compounds, a series of new triazole derivatives containing pyridine moiety were synthesized by the introduction of the important pyridyl backbone into the molecules of triazoles. They were structurally confirmed by ¹H NMR, ¹³C NMR, IR, MS and elemental analysis. Additionally, compound 4k was structurally characterized through X-ray single crystal diffraction method. Preliminary bioassay data showed that some of the title compounds displayed moderate fungicidal and plant growth regulatory activities.

Key words: triazole, pyridine, synthesis, bioactivity

Cite this article

Dai Hong, Liu Jianbing, Tao Weifeng, Miao Wenke, Fang Jianxin, Wang Qingmin. Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones[J]. Chin. J. Org. Chem., 2016, 36(2): 393-398.

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1-(吡啶-2-基)-2-芳氧基-2-(α-1H-1,2,4-三唑-1-基)乙酮的合成、晶体结构与生物活性

Synthesis, Crystal Structure and Biological Activity of Novel 1-(Pyridin-2-yl)-2-aryloxy-2-(1H-1,2,4-triazol-1-yl)ethanones

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