Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent

doi:10.6023/cjoc201510031

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 1060-1064.DOI: 10.6023/cjoc201510031 Previous Articles Next Articles

ARTICLE

铁催化二级氯代烷烃与炔基格氏试剂的交叉偶联反应

贾婉^a, 赵立志^b, 魏恒旭^b, 朱林东^b, 傅磊^a, 陈蔚春^b

a. 上海交通大学药学院上海 200240;
b. 葛兰素史克上海医药研发有限公司上海 201203

收稿日期:2015-10-26 修回日期:2015-12-16 发布日期:2016-01-04
通讯作者: 陈蔚春 E-mail:weichun.w.chen@gsk.com
基金资助:
葛兰素史克(上海)医药研发有限公司与上海交通大学药学院联合培养项目.

Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent

Jia Wan^a, Zhao Lizhi^b, Wei Hengxu^b, Zhu Lindong^b, Fu Lei^a, Chen Weichun^b

a. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240;
b. Research and Developemnt Center in Shanghai of GlaxoSmithKline, Shanghai 201203

Received:2015-10-26 Revised:2015-12-16 Published:2016-01-04
Supported by:
Project supported by the Union-Education Program of Shanghai Jiao Tong University and the Research and Development Center of GlaxoSmithKline.

1. Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent.PDF(533KB)

Abstract

A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.

Key words: iron-catalyzed, secondary alkyl choloride, alkynes Grignard reagents, cross-coupling reactions, green chemistry

Cite this article

Jia Wan, Zhao Lizhi, Wei Hengxu, Zhu Lindong, Fu Lei, Chen Weichun. Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent[J]. Chin. J. Org. Chem., 2016, 36(5): 1060-1064.

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铁催化二级氯代烷烃与炔基格氏试剂的交叉偶联反应

Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent

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