Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 1985-1993.DOI: 10.6023/cjoc201604036 Previous Articles     Next Articles

REVIEW

过渡金属催化合成胍类衍生物研究进展

徐树英a, 陈小佳b, 黎吉辉a, 许文茸a, 张玉苍a   

  1. a 海南大学材料与化工学院 海口 570228;
    b 海南省产品质量监督检验所 海口 570003
  • 收稿日期:2016-04-18 修回日期:2016-05-16 发布日期:2016-06-20
  • 通讯作者: 黎吉辉, 张玉苍 E-mail:lijihui@hainu.edu.cn;zhangyucang88@163.com
  • 基金资助:

    海南省自然科学基金(Nos.20162015,20152027)、海南省国际科技合作专项(No.KJHZ2014-02)、教育部高等学校博士学科点专项科研基金(No.20134601110004)资助项目.

Recent Advances in Transition Metal-Catalyzed Synthesis of Guanidines

Xu Shuyinga, Chen Xiaojiab, Li Jihuia, Xu Wenronga, Zhang Yucanga   

  1. a College of Materials and Chemical Engineering, Hainan University, Haikou 570228;
    b Products Quality Supervision and Testing Institute of Hainan Province, Haikou 570003
  • Received:2016-04-18 Revised:2016-05-16 Published:2016-06-20
  • Supported by:

    Project supported by the Natural Science Fundation of Hainan Province (Nos.20162015, 20152027), the Hainan Province International Science and Technology Specific (No.KJHZ2014-02) and the Research Fund for the Doctoral Program of Higher Education of China (No.20134601110004).

Guanidines are a unique class of tri-nitrogen compounds having various bioactivities, which are wildly presented in natural products and drug molecules, and they are wildly used in pharmacy and pesticide fields. Moreover, they have high application value in organic synthesis and functional materials. The synthesis of guanidines has received much attention due to their unique structures and widespread application value. Recently, lots of new synthetic methods of guanidines, especially the synthetic methods based on highly efficient transition metal-catalyzed reactions, have been developed. The recent progress in transition metal-catalyzed reactions developed for the synthesis of guanidines in the past twenty years is summarized. The synthetic methods for various guanidines are introduced comprehensively, and the characteristics and disadvantages of these methods are also discussed, thus it may be helpful for the research on transition metal-catalyzed synthesis of guanidines.

Key words: transition metal-catalyzed, C-N formation reaction, guanidines, synthetic method