Efficient Synthesis of Epilactose

doi:10.6023/cjoc201608010

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 375-384.DOI: 10.6023/cjoc201608010 Previous Articles Next Articles

ARTICLE

表乳糖的合成研究

王家尧, 姜锐, 梁晓梅, 金淑惠, 王道全, 张建军

中国农业大学理学院北京 100193

收稿日期:2016-08-17 修回日期:2016-10-08 发布日期:2016-11-03
通讯作者: 金淑惠, 张建军 E-mail:shuhuij@cau.edu.cn;zhangjianjun@cau.edu.cn
基金资助:
国家科技支撑计划（No.2015BAK45B01）资助项目.

Efficient Synthesis of Epilactose

Wang Jiayao, Jiang Rui, Liang Xiaomei, Jin Shuhui, Wang Daoquan, Zhang Jianjun

China Agricultural University, Beijing 100193

Received:2016-08-17 Revised:2016-10-08 Published:2016-11-03
Supported by:
Project supported by the National Science & Technology Pillar Program of China (No. 2015BAK45B01).

1. Efficient Synthesis of Epilactose.PDF(1012KB)

Abstract

Epilactose (4-O-β-D-galactopyranosyl-D-mannose) is a reducing disaccharide with satisfactory prebiotic properties. A superior synthetic methods were confirmed by screening different coupled donors and acceptors which were synthesized from D-mannose and D-galactose, respectively. This route gets 50% overall yields and all the intermediates are easily to be purified, making the route suitable for large scale preparation of the target compound. All the compounds were characterized by NMR and HRMS spectra.

Key words: epilactose, D-mannose, D-galactose, synthesis

Cite this article

Wang Jiayao, Jiang Rui, Liang Xiaomei, Jin Shuhui, Wang Daoquan, Zhang Jianjun. Efficient Synthesis of Epilactose[J]. Chin. J. Org. Chem., 2017, 37(2): 375-384.

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表乳糖的合成研究

Efficient Synthesis of Epilactose

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